I think I can speak to LSP as a beta tester and as someone that sequenced 2,800 channels last year (mostly RGB) in LSP. LSP made some major jumps in ability last year to be able to handle 10k channels and some complex new hardware that was introduced. I won't say it wasn't problem free but LSP went through a number of revisions to be able to step up to the plate and work with these large number of channels (the developer also had a large number of RGB channels in 2010). The one thing that still was lacking was minor little "issues", mostly in the UI - things like cut-n-paste, scrolling, timing marks, etc - nothing you couldn't work around but they were just annoying.
A number of the beta testers discussed what they felt needed the most attention in the new revision and there were two major priorities - speed and fixing of all the minor UI bugs. The developer has already released information that shows the speed (it went from single threaded to multi-threaded) has increased, file sizes have dropped and memory requirements are lower, even on large sequences. According to what I'm seein in the bug tracker, they are also resolving the outstanding UI related issues.
So, a release is coming in the near future and I'm sure it will be really amazing.