Pretty much. If you use S2 and the LOR dongle, then you are sending commands in LOR native mode so you have access to the LOR hardware built in functions. If you put the LOR units in DMX mode and use a DMX dongle, then these commands and functions are no longer available and you will need to issue a constant stream of DMX commands to simulate these functions. Fortunantly, some of the DMX sequencing software has built in functions that will help you to do this. If you want to use RJ's TX/RX units, they are DMX only devices and using them with LOR units will require the LOR units to be used in DMX only mode.