I use xLights to run the show. It has a user-friendly interface and seems to load things more smoothly than the Vixen scheduler. If I were using just the Vixen scheduler, I would make the entire show 1 big sequence. That's just me though.
Other logistics for automation: Expresses, hub, FM transmitter, and inflatable fans are on timers. Granted, none of these use a ton of power in an idle state, but then again, power-cycling hardware is never bad.