In LSP, make sure your controllers connected to the USB DMX are set to ettec DMX Pro. For the controllers connected to the Ethernet, set the protocol to E1.31. Then, go to the output controller plug-in and make sure each is configured.
This should work, but you may find some timing issues. For smoother setup, I would recommend running everything off E1.31 and the hub(s). Even if you need to get another box or longer cord.